Shop for Colic Remedies Go Back To Main Shopping Page BioGaia ProBiotic Drops What are ProBiotics? Probiotics are beneficial bacteria that, when administered in adequate amounts, confer a health benefit. Probiotics contain live cultures similar to those found in some yogurts and fermented milks. The word probiotic means "for life." Probiotics are supplements just like vitamins and minerals. What Is BioGaia? BioGaia is a brand of probiotic supplements designed for people of all ages. BioGaia contains L. reuteri Protectis, a natural lactobacilli that has been tested in numerous clinical trials and proven effective as well as safe for children.* [1-39] How is BioGaia Different From Other ProBiotics? It is important to understand that probiotic supplements contain different strains of bacteria. Experts believe that these different strains have different health benefits. Therefore, it is important to choose your probiotic supplement carefully. Look for products that have been tested for safety and clinically shown to promote good health, like BioGaia.* [1-39] Can I Give My Child BioGaia Everyday and Is It Safe? Yes. Children's tummies get bombarded daily by allergens and pathogens mostly through their food and drink . This constant exposure can upset the natural balance of your child's gut flora. BioGaia helps the good guys restore a natural balance to promote nutritional uptake, protect the gut and strengthen immunity.* [1,3,6,7,14,18-21,25-29,37,40-42] Can BioGaia ProBiotic Drops Help Calm My Baby's Colic? There is a study that is published in Pediatrics [9] that has shown that the probiotic strain, L. reuteri Protectis, can make a dramatic difference in the amount of time your colicky baby cries. The brief synopsis of the study is below: OBJECTIVE. The goal was to test the hypothesis that oral administration of Lactobacillus reuteri in a prospective randomized study would improve symptoms of infantile colic. METHODS. Ninety breastfed colicky infants were assigned randomly to receive either the probiotic L reuteri (108 live bacteria per day) or simethicone (60 mg/day) each day for 28 days. The mothers avoided cow's milk in their diet. Parents monitored daily crying times and adverse effects by using a questionnaire. RESULTS. Eighty-three infants completed the trial: 41 in the probiotic group and 42 in the simethicone group. The infants were similar regarding gestational age, birth weight, gender, and crying time at baseline. Daily median crying times in the probiotic and simethicone groups were 159 minutes/day and 177 minutes/day, respectively, on the seventh day and 51 minutes/day and 145 minutes/day on the 28th day. On day 28, 39 patients (95%) were responders in the probiotic group and 3 patients (7%) were responders in the simethicone group. No adverse effects were reported. CONCLUSIONS. In our cohort, L reuteri improved colicky symptoms in breastfed infants within 1 week of treatment, compared with simethicone, which suggests that probiotics may have a role in the treatment of infantile colic. The study showed that at the 28 day mark of taking the probiotics, the average crying time had decreased from 159 minutes a day to 51 minutes a day and that 95% of the study participants had significant improvement in crying time. The simethicone group only had 7% of the participants show improvement. Watch ABC News Special Report on ProBiotics and Colic | Read Scientific Study Published in Pediatrics BioGaia ProBiotic Drops Information SUPPLEMENT FACTS: Serving size: 5 drops 25 servings per container Amount per serving: Lactobacillus reuteri Protectis, 100 million live, active cells* * Daily Value not established. Other ingredients: Sunflower oil, medium chain triglyceride oil, silicon dioxide. USAGE: Five (5) drops per day or as directed by your health care professional. Shake well before use. To dispense, tip the bottle at an angle of around 45 degrees and the drops will form slowly. The drops may be given on a spoon or added to any suitable drink or food. After use, tap the bottom of the bottle gently to clear the dispenser. Do not add to hot food or drink as this may damage the live cultures. The drops do not change the taste of food or drink. STORAGE: Keep refrigerated. Please Note: Please note that BioGaia Probiotic Drops are shipped with packing designed to provide thermal protection. For this reason, orders will only be shipped Monday through Wednesday. Orders placed by 2:30 pm ET will be shipped out the same day. If you would like your order shipped on Thursday or Friday, please contact us for overnight shipping rates. You can contact us at 1-888-227-6718 and we will be able to provide a shipping quote for you. BioGaia ProBiotic Drops $36.99 Qty. References: 1. Abrahamsson, T.R., et al. (2007) Probiotics in Prevention of IgE-Associated Eczema: A Double-Blind, Randomized, Placebo-Controlled Trial. J Allergy Clin Immunol, 119, 1174-80. 2. Reuter, G. (2001) The Lactobacillus and Bifidobacterium Microflora of the Human Intestine: Composition and Succession. Curr Issues Intest Microbiol, 2, 43-53. 3. Valeur, N., et al. (2004) Colonization and Immunomodulation by Lactobacillus reuteri ATCC 55730 in the Human Gastrointestinal Tract. Appl Environ Microbiol, 70, 1176-81. 4. Abrahamsson, T., et al. (2005) Intestinal Microbiota in Infants Supplemented with the Probiotic Bacterium Lactobacillus reuteri. J Pediatr Gastroenterol Nutr, 40, PN1-17. 5. Romeo, M.G., et al. (2006) The Role of Probiotics in the Prevention of Bacterial and Candida Infections in Neonatal Intensive Care. Prospective Study with Control Group. J Perinat Med, 34, A9, abstract MSL24. 6. Weizman, Z., et al. (2005) Effect of a Probiotic Infant Formula on Infections in Child Care Centers: Comparison of Two Probiotic Agents. Pediatrics, 115, 5-9. 7. Ruiz-Palacios, G., et al. (1996) Feeding of a Probiotic for the Prevention of Community-Acquired Diarrhea in Young Mexican Children. Pediatr Res, 39, Part 2: 184A Abstract 1089. 8. Guerrero, M.L., et al. (1996) Effect of Probiotic-Containing Beverages on Incidence of Diarrhoea. 1st World Congress of Pediatric Infectious Diseases, Acapulco, Mexico . 9. Savino, F., et al. (2007) Lactobacillus reuteri (American Type Culture Collection Strain 55730) Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Study. Pediatrics, 119, e124-30. 10. Lionetti, E., et al. (2006) Lactobacillus Reuteri Therapy to Reduce Side-Effects During Anti-Helicobacter pylori Treatment in Children: A Randomized Placebo Controlled Trial. Aliment Pharmacol Ther, 24, 1461-8. 11. Eom, T.H., et al. (2005) The Therapeutic Effect of Lactobacillus reuteri in Acute Diarrhea in Infants and Toddlers. Korean J Ped, 48, 986-9. 12. Shornikova, A.V., et al. (1997) Lactobacillus reuteri as a Therapeutic Agent in Acute Diarrhea in Young Children. J Pediatr Gastroenterol Nutr, 24, 399-404. 13. Shornikova, A.V., et al. (1997) Bacteriotherapy with Lactobacillus reuteri in Rotavirus Gastroenteritis. Pediatr Infect Dis J, 16, 1103-7. 14. Cirillo, A., et al. (2005) Effectiveness of L. reuteri in Patients with Atopic Dermatitis and Cow Milk Intolerance. Preliminary Study. Italian Society for Clinical Allergy and Immunology Congress, Rome, Italy . 15. Weizman, Z., et al. (2006) Safety and Tolerance of a Probiotic Formula in Early Infancy Comparing Two Probiotic Agents: A Pilot Study. J Am Coll Nutr, 25, 415-9. 16. Connolly, E., et al. (2005) Safety of D(-)-Lactic Acid Producing Bacteria in the Human Infant. J Pediatr Gastroenterol Nutr, 41, 489-92. 17. Karvonen, A., et al. (2001) Safety and Possible Antidiarrhoel Effect of the Probiotic Lactobaciullus reuteri after Oral Administration to Neonates. Clin Nutr, 20, 63 abstract 216. 18. Ruiz-Palacios, G., et al. (1996) Tolerance and Fecal Colonization with Lactobacillus reuteri in Children Fed a Beverage with a Mixture of Lactobacillus Sp. Pediatr Res, 39, 104A. 19. Dobrogosz, W.J. (2005) Enhancement of Human Health with Lactobacillus reuteri a Probiotic, Immunobiotic and Immunoprobiotic. Nutrafoods, vol. 4, pp. 15-28. 20. Connolly, E. (2004) Lactobacillus reuteri ATCC 55730 a Clinically Proven Probiotic. Nutrafoods, vol. 3, pp. 15-22. 21. Casas, I.A., et al. (2000) Validation of the Probiotic Concept: Lactobacillus reuteri Confers Broad-Spectrum Protection against Disease in Humans and Animals. Microbial Ecology in Health and Disease, 12, 247-85. 22. Elliott, E., et al. (2004) An Evaluation of Nine Probiotics Available in South Africa , August 2003. S Afr Med J, 94, 121-4. 23. Temmerman, R., et al. (2003) Identification and Antibiotic Susceptibility of Bacterial Isolates from Probiotic Products. Int J Food Microbiol, 81, 1-10. 24. Connolly, E. (2005) Lactobacillus reuteri Drops Novel Delivery System. NutraFoods, vol. 4, pp. 65-8. 25. Jakobsson, T., et al. (2005) The Effect of Oral Supplementation of Lactobacillus reuteri on the Immunologic Composition of Breast Milk. J Pediatr Gastroenterol Nutr, 40, 624. 26. Bjorkman, P. (1999) Colonization of the Human Gastrointestinal Tract by the Lactic Acid Bacteria Lactobacillus reuteri. Department of Food Technology. University of Helsinki, Finland . 27. Tubelius, P., et al. (2005) Increasing Work-Place Healthiness with the Probiotic Lactobacillus reuteri: A Randomised, Double-Blind Placebo-Controlled Study. Environ Health, 4, 25. 28. Imase, K., et al. (2007) Lactobacillus reuteri Tablets Suppress Helicobacter pylori Infection: A Double-Blind, Randomised, Placebo-Controlled Crossover Clinical Study. Kansenshogaku Zasshi (Journal of the Japanese Association for Infectious Diseases), 81, 387-93. 29. Saggioro, A. (2005) Heliobacter pylori Eradication with Lactobacillus reuteri. A Double-Blind Placebo-Controlled Study. Digestive and Liver Diseases, 37, S88. 30. Niv, E., et al. (2005) The Efficacy of Lactobacillus reuteri ATCC 55730 in the Treatment of Patients with Irritable Bowel Syndrome--a Double Blind, Placebo-Controlled, Randomized Study. Clin Nutr, 24, 925-31. 31. Ouwehand, A.C., et al. (2002) Effect of Probiotics on Constipation, Fecal Azoreductase Activity and Fecal Mucin Content in the Elderly. Ann Nutr Metab, 46, 159-62. 32. Krasse, P., et al. (2006) Decreased Gum Bleeding and Reduced Gingivitis by the Probiotic Lactobacillus reuteri. Swed Dent J, 30, 55-60. 33. Caglar, E., et al. (2006) Salivary Mutans Streptococci and Lactobacilli Levels after Ingestion of the Probiotic Bacterium Lactobacillus reuteri ATCC 55730 by Straws or Tablets. Acta Odontol Scand, 64, 314-8. 34. Nikawa, H., et al. (2004) Lactobacillus reuteri in Bovine Milk Fermented Decreases the Oral Carriage of Mutans Streptococci. Int J Food Microbiol, 95, 219-23. 35. Wolf, B.W., et al. (1998) Safety and Tolerance of Lactobacillus reuteri Supplementation to a Population Infected with the Human Immunodeficiency Virus. Food Chem Toxicol, 36, 1085-94. 36. Wolf, B.W., et al. (1995) Safety and Tolerance of Lactobaciullus reuteri in Healthy Adult Male Subjects. Microbial Ecology in Health and Disease, 8, 41-50. 37. Betta, P., et al. (2007) Probiotics in the Prevention of Bacterial and Candida Infections in Newborns Submitted to Greater Surgical Interventions and Admitted in NICU-Retrospective Group Controlled Study. J Pediatr Gastroenterol Nutr, 44, Abstract PG 4-13. 38. Sinkiewicz, G., et al. (2005) Occurence of Lactobacillus reuteri, Lactobacilli and Bifidobacteria in Human Breast Milk. Pediatr Res, 58, Abstract 353. 39. Gibson, G.R., et al. (2005) An Evaluation of Probiotic Effects in the Human Gut: Microbial Aspects. Final Technical Report for Food Standards Agency (FSA) Project Ref G01022. 40. Schultz, M., et al. (2004) Administration of Oral Probiotic Bacteria to Pregnant Women Causes Temporary Infantile Colonization. J Pediatr Gastroenterol Nutr, 38, 293-7. 41. Romeo, M.G., et al. (2006) Effect of Probiotics on Enteral Feeding of Premature Infants. J Perinat Med, 34, Abstract MSL_24. 42. Kalliomaki, M., et al. (2001) Probiotics in Primary Prevention of Atopic Disease: A Randomised Placebo-Controlled Trial. Lancet, 357, 1076-9. 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